業績

英語論文（2010年以降）

橋本　均
 ResearcherID （Thomson Reuters）

2024年

  1. Yokoyama R, Ago Y, Igarashi H, Higuchi M, Tanuma M, Shimazaki Y, Kawai T, Seiriki K, Hayashida M, Yamaguchi S, Tanaka H, Nakazawa T, Okamura Y, Hashimoto K, Kasai A, Hashimoto H.  (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.  Molecular Psychiatry , 2024
  2. Hirato Y, Seiriki K, Kojima L, Yamada S, Rokujo H, Takemoto T, Nakazawa T, Kasai A, Hashimoto H. Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner.  Biological and Pharmaceutical Bulletin 47(2):478-485. ,2024
  3. Kojima L, Seiriki K, Rokujo H, Nakazawa T, Kasai A, Hashimoto H. Optimization of AAV vectors for transactivator-regulated enhanced gene expression within targeted neuronal populations. iScience  3;27(6):109878 , 2024

2023年

  1. Asano S, Ono A, Sakamoto K, Hayata-Takano A, Nakazawa T, Tanimoto K, Hashimoto H, Ago Y. Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway. Petitdes 161:170940, 2023
  2. Eguchi M, Hirata S, Ishigami I, Shuwari N, Ono R, Tachibana M, Tanuma M, Kasai A, Hashimoto H, Ogawara KI, Mizuguchi H, Sakurai F. Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes. J Control Release 354:35-44, 2023
  3. Kambe Y, Nguyen TT, Yasaka T, Nguyen TT, Sameshima Y, Hashiguchi K, Shintani N, Hashimoto H, Kurihara T, Miyata A. The pivotal role of neuropeptide crosstalk from ventromedial-PACAP to dorsomedial-galanin in the appetite regulation in the mouse hypothalamus. Mol Neurobiol 60:171-182, 2023
  4. Ago Y, Yokoyama R, Asano S, Hashimoto H. Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites. Neuropharmacology 223:109313, 2023

2022年

  1. Nagashima T, Tohyama S, Mikami K, Nagase M, Morishima M, Kasai A, Hashimoto H, Watabe AM. Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice. Nat Commun 13:7913, 2022
  2. Tanuma M, Niu M, Ohkubo J, Ueno H, Nakai Y, Yokoyama Y, Seiriki K, Hashimoto H, Kasai A. Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala. Mol Brain 15:100, 2022
  3. Endo F, Kasai A, Soto JS, Yu X, Qu Z, Hashimoto H, Gradinaru V, Kawaguchi R, Khakh BS. Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science 378:eadc9020, 2022
  4. Asano S, Yamasaka M, Ozasa K, Sakamoto K, Hayata-Takano A, Nakazawa T, Hashimoto H, Waschek JA, Ago Y. Vasoactive intestinal peptide-VIPR2 signaling regulates tumor cell migration. Front Oncol 12:852358, 2022
  5. Gaszner T, Farkas J, Kun D, Ujv$00E1ri B, F$00FCredi N, Kov$00E1cs L$00C1, Hashimoto H, Regl$0151di D, Kormos V, Gaszner B. Epigenetic and neuronal activity markers suggest the recruitment of the prefrontal cortex and hippocampus in the three-hit model of depression in male PACAP Heterozygous mice. Int J Mol Sci 23:11739, 2022
  6. Gaszner T, Farkas J, Kun D, Ujv$00E1ri B, Berta G, Csernus V, F$00FCredi N, Kov$00E1cs L$00C1, Hashimoto H, Regl$0151di D, Kormos V, Gaszner B. Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy. Front Endocrinol (Lausanne). 13:995900, 2022
  7. Shintani Y, Yamano Y, Kuta M, Takeshita R, Takuma K, Okada T, Toyooka N, Takasaki I, Miyata A, Kurihara T, Hashimoto H, Hayata-Takano A. Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice. Biochem BioPhys Res Commun 631:146-151, 2022
  8. Takemoto T, Baba M, Yokoyama K, Kitagawa K, Nagayasu K, Ago Y, Seiriki K, Hayata-Takano A, Kasai A, Mori D, Ozaki N, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Molecular brain (micro report) oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome. Mol Brain 15:26, 2022
  9. Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H. Claustrum mediates bidrectional and reversible control of stress-induced anxiety responses. Sci Adv 8:eabi6375, 2022
  10. Kawano S, Baba M, Fukushima H, Miura D, Hashimoto H, Nakazawa T. Autism-associated ANK2 regulates embryonic neurodevelopment. Biochem BioPhys Res Commun 605:45-50, 2022

2021年

  1. Hayata-Takano A, Shintani Y, Moriguchi K, Encho N, Kitagawa K, Nakazawa T, Hashimoto H. PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization. Front Endocrinol (Lausanne) 12:732456, 2021
  2. Yamamoto K, Kuriu T, Matsumura K, Nagayasu K, Tsurusaki Y, Miyake N, Yamamori H, Yasuda Y, Fujimoto M, Fujiwara M, Baba M, Kitagawa K, Takemoto T, Gotoda-Nishimura N, Takada T, Seiriki K, Hayata-Takano A, Kasai A, Ago T, Kisa S, Takuma K, Ono F, Matsumoto N, Hashimoto R, Hashimoto H, Nakazawa T. Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia. Transl Psychiatry 11:548, 2021
  3. Togo K, Fukusumi H, Shofuda T, Ohnishi H, Yamazaki H, Hayashi MK, Kawasaki N, Takei N, Nakazawa T, Saito Y, Baba K, Hashimoto H, Sekino Y, Shirao T, Mochizuki H, Kanemura Y. Postsynaptic structure formation of huma iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro. Mol Brain 14:149, 2021
  4. Ago Y, Asano S, Hashimoto H, Waschek JA. Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models. Front Neurosci 15:717490, 2021
  5. Kvarik T, Reglodi D, Werling D, Vaczy A, Kovari P, Szabo E, Kovacs K, Hashimoto H, Ertl T, Gyarmati J, Atlasz T. The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy. J Mol Neurosci 71:2546-2557, 2021
  6. Kambe Y, Yamauchi Y, Thanh Nguyen T, Thi Nguyen T, Ago Y, Shintani N, Hashimoto H, Yoshitake S, Yoshitake T, Kehr J, Kawamura N, Katsuura G, Kurihara T, Miyata A. The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory. Pharmacol Rep 73:1109-1121, 2021
  7. Niu M, Kasai A, Seiriki K, Hayashida M, Tanuma M, Yokoyama R, Hirato Y, Hashimoto H. Altered functional connectivity the orbital cortex and striatum associated with catalepsy induced by dopamine D1 and D2 antagonists. Biol Pharm Bull 44:442-447, 2021
  8. Kitagawa K, Matsumura K, Baba M, Kondo M, Takemoto T, Nagayasu K, Ago Y, Seiriki K, Hayata-Takano A, Kasai A, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Intranasal oxytocin administration ameliorates social behavioral deficits in POGZWT/Q1038R mouse model of autism spectrum disorder. Mol Brain 14:56, 2021
  9. Yoshinaga S, Shin M, Kitazawa A, Ishii K, Tanuma M, Kasai A, Hashimoto H, Kubo KI, Nakajima K. Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling. iScience 24:102277, 2021

2020年

  1. Kawaguchi C, Shintani N, Hayata-Takano A, Hatanaka M, Kuromi A, Nakamura R, Yamano Y, Shintani Y, Nagai K, Tsuchiya S, Sugimoto Y, Ichikawa A, Okuno Y, Urade Y, Hirai H, Nagata KY, Nakamura M, Narumiya S, Nakazawa T, Kasai A, Ago Y, Takuma K, Baba A, Hashimoto H. Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice. Commun Biol 3:557, 2020
  2. Takeuchi S, Kawanai T, Yamauchi R, Chen L, Miyaoka T, Yamada M, Asano S, Hayata-Takano A, Nakazawa T, Yano K, Horiguchi N, Nakagawa S, Takuma K, Waschek JA, Hashimoto H, Ago Y. Activation of the VPAC2 receptor impairs axon outgrowth and decreases dendritic arborization in mouse corticalneurons by a PKA-dependent mechanism. Front Neurosci 14:521, 2020
  3. Tanuma M, Kasai A, Bando K, Kotoku N, Harada K, Minoshima M, Higashino K, Kimishima A, Arai M, Ago Y, Seiriki K, Kikuchi K, Kawata S, Fujita K, Hashimoto H. Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain. JCI Insight 5:e133348, 2020
  4. Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, Furuse T, Shibuya H, Yasuda Y, Yamamori H, Fujimoto M, Nagayasu K, Yamamoto K, Kitagawa K, Miura H, Gotoda-Nishimura N, Igarashi H, Hayashida M, Baba M, Kondo M, Hasebe S, Ueshima K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Yamaguchi S, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nat Commun 11:859, 2020
  5. Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, Chen L, Kasai A, Seiriki K, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H, Ago Y. (S)-norketamine and (2S, 6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. Pharmacol Biochem Behav 191:172876, 2020
  6. Nguyen TT, Kambe Y, Kurihara T, Nakamachi T, Shintani N, Hashimoto H, Miyata A. Pituitary adenylate cyclase activating polypeptide in the ventromedial hypothalamus is responsivle for food intake behavior by modulating the expression of agouti-related peptide in mice. Mol Neurobiol 57:2101-2114, 2020

2019年

  1. Fulop DB, Humli V, Szepesy J, Ott V, Reglodi D, Gaszner B, Nemeth A, Szirmai A, Tamas L, Hashimoto H, Zelles T, Tamas A. Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. Sci Rep 9:14598, 2019
  2. Matsumura K, Baba M, Nagayasu K, Yamamoto K, Kondo M, Kitagawa K, Takemoto T, Seiriki K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Kuriu T, Sato M, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Autism-associated protein kinase D2 regulates embryonic cortical neuron development. Biochem Biophys Res Commun 519:626-632, 2019
  3. Ago Y, Tanabe W, Higuchi M, Tsukada S, Tanaka T, Yamaguchi T, Igarashi H, Yokoyama R, Seiriki K, Kasai A, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H. (R)-ketamine induces a greater increase in prefrontal 5-HT release than (S)-ketamine and ketamine metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22:665-674, 2019
  4. Nakazawa T, Hashimoto R, Takuma K, Hashimoto H. Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies. J Pharmacol Sci 140:321-324, 2019
  5. Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. Neuropsychopharmacol 44:2125-2135, 2019
  6. Fulop DB, Sandor B, Szentleleky E, Karanyicz E, Reglodi D, Gaszner B, Zakany R, Hashimoto H, Juhasz T, Tamas A. Altered notch signaling in developing molar teeth of pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. J Mol Neurobiol 68:377, 2019
  7. Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H. Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST. Nat Protoc 14:1509-1529, 2019
  8. Hayata-Takano A, Kamo T, Kijima H, Seiriki K, Ogata K, Ago Y, Nakazawa T, Shintani Y, Higashino K, Nagayasu K, Shintani N, Kasai A, Waschek JA, Hashimoto H. Pituitary adenylate cyclase-activating polypeptide modulates dendritic spine maturation and morphogenesis via microRNA-132 upregulation. J Neurosci 39:4208-4220, 2019
  9. Li J, Hashimoto H, Meltzer HY. Association of serotonin2c receptor polymorphisms with antipsychotic drug response in schizophrenia. Front Psychiatry 10:58, 2019
  10. Ivic I, Balasko M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D, Solymar M. VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice. PLoS One 14:e0211433, 2019
  11. Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H. mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model. Pharmacol Biochem Behav 176: 1-5, 2019
  12. Nishitani N, Nagayasu K, Asaoka N, Yamashiro M, Andoh C, Nagai Y, Kinoshita H, Kawai H, Shibui N, Liu B, Hewinson J, Shirakawa H, Nakagawa T, Hashimoto H, Kasparov S, Kaneko S. Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacol 44:721-732, 2019

2018年

  1. Nawa Y, Yonemaru Y, Kasai A, Oketani R, Hashimoto H, Smith NI, Fijita K. Saturated excitation microscopy using differential excitation for efficient detection of nonlinear fluorescence signals. APL Photonics 3:080805, 2018
  2. Reglodi D, Jungling A, Longuespee R, Kriegsmann J, Casadonte R, Kriegsmann M, Juhasz T, Bardosi S, Tamas A, Fulop BD, Kovacs A, Nagy Z, Sparks J, Miseta A, Mazzucchelli G, Hashimoto H, Bardosi A. Accelerated pre-senile systemic amyloidosis in PACAP knockout mice- a protective role of PACAP in age-related degenerative processes. J Pathol 245:478-490, 2018
  3. Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H. beta-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. PLoS One 13:e0196946, 2018
  4. Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N. Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response. Biochem Biophys Res Commun 495: 1992-1997, 2018
  5. Reglodi D, Cseh S, Somoskoi B, Fulop BD, Szentleleky E, Szegeczki V, Kovacs A, Varga A, Kiss P, Hashimoto H, Tamas A, Bardosi A, Manavalan S, Bako E, Zakany R, Juhasz T. Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice. Reproduction 155:127, 2018
  6. Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki S, Shintani Y, Shintani N, Hashimoto H. Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism. EMBO Rep 19: e44860, 2018

2017年

  1. Ivic I, Solymar M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D. Aging-induced modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-induced vasomotor responses in the arteries of mice. J Vasc Res 54:359-366, 2017
  2. Farkas J, Kovacs LA, Gaspar L, Nafz A, Gaszner T, Ujvari B, Kormos V, Csernus V, Hashimoto H, Reglodi D, Gaszner B. Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background. Neurosci 354:11, 2017
  3. Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman JD, Rajbhandari AK, Franselow MS, Hashimoto H, Waschek JA. Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice. Neurobiol Learn Mem 145:222-231, 2017
  4. Hara Y, Ago Y, Higuchi M, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism. Horm Behav 96: 130-136, 2017
  5. Hara Y, Ago Y, Taruta A, Hasebe S, Kawase H, Tanabe W, Tsukada S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice. Psychopharmacol (Berl) 234: 3217-3228, 2017
  6. Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain. Mol Autism 8: 33, 2017
  7. Yamaguchi H, Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K. Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice. Behav Brain Res 333: 67-73, 2017
  8. Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H. High-speed and scalable whole-brain imaging in rodents and primates. Neuron 94: 1085-1100, 2017
  9. Ago Y, Hasebe S, Hiramatsu N, Hashimoto H, Takuma K, Matsuda T. Psychopharmacology of combined activation of the serotonin 1A and sigma1 receptors. Eur J Pharmacol 809: 172-177, 2017
  10. Ivic I, Fulop BD, Juhasz T, Reglodi D, Toth G, Hashimoto H, Tamas A, Koller A. Backup mechanisms maintain PACAP/VIP-induced arterial relaxations in pituitary adenylate cyclase-activating polypeptide-deficient mice. J Vasc Res 54: 180-192, 2017
  11. Farkas J, Kovacs LA, Gaspar L, Nafz A, Gaszner T, Ujvari B, Kormos V, Csernus V, Hashimoto H, Reglodi D, Gaszner B. Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background. Neurosci 354: 11-29, 2017
  12. Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J Exp Med 214: 1431-1452, 2017
  13. Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T. Effct of clozapine on DNA methylation in peripheral leukocytes from patients with treatment-resistant schizophrenia. Int J Mol Sci 18: pii:E632, 2017
  14. Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophr Res 181: 75-82, 2017
  15. Farkas J, Sandor B, Tamas A, Kiss P, Hashimoto H, Nagy AD, Fulop BD, Juhasz T, Manavalan S, Reglodi D. Early Neurobehavioral development of mice lacking endogenous PACAP. J Mol Neurosci 61: 568-578, 2017
  16. Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto T, Takuma K, Matsuda T. Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hypercactivity in methamphetamine-sensitized mice. Int J Neuropsychopharmacol 20: 410-421, 2017
  17. Hasebe S, Ago Y, Watabe Y, Oka S, Hiramatsu N, Tanaka T, Umehara C, Hashimoto H, Takuma K, Matsuda T. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol 174: 314-327, 2017
  18. Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T. Effect of clozapine on DNA methylation in pheripheral leukocytes from patients with treatment-resistant schizophrenia. Int J Mol Sci 18:E632, 2017
  19. Sasaki S, Watanabe H, Ohtani H, Matsumoto M, Murai N, Nakamachi T, Hannibal H, Fahrenkrug J, Hashimoto H, Watanabe H, Sueki H, Honda K, Miyazaki A, Shioda S. Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion. British J Dermatol 176:413, 2017
  20. Haruta M, Kamiyama N, Nakajima S, Motoyama M, Kawahara M, Ohta Y, Yamasaki M, Takehara H, Noda T, Sasagawa K, Ishikawa Y, Tokuda T, Hashimoto H, Ohta J. Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation. Jpn J Appl Phys 56:057001, 2017
  21. Lacaille H, Duterte-Boucher D, Vaudry H, Zerdoumi Y, Flaman JM, Hashimoto H, Vaudry D. PACAP protects the adolescent and adult mice brain from ethanol toxicity and modulates distinct sets of genes regulating similar networks. Mol Neurobiol 54:7534, 2017

2016年

  1. Structural and morphometric comparison of lower incisors in PACAP-deficient and wild-type mice. J Mol Neurosci 59:300, 2016
  2. Kasai A, Kakihara S, Miura H, Okada R, Hayata-Takano A, Hazama K, Niu M, Shintani N, Nakazawa T, Hashimoto H. Double in situ hybridization for microRNAs and mRNAs in brain tissues. Front Mol Neurosci 9: 126, 2016
  3. Nakata M, Zhang B, Yang Y, Okada T, Shintani N, Hashimoto H, Yada T. High-fat diet augments VPAC1 receptor-mediated PACAP action on the liver, including LAR expression and insulin resistance.J Diabetes Res 2016: 9321395, 2016
  4. Seiriki K, Kasai A, Kuwaki T, Nakazawa T, Yamaguchi S, Hashimoto H. Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice.Biochem Biophys Res Commun 480: 558-563, 2016
  5. Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H. Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction. Behav Brain Res 314: 77-86, 2016
  6. Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Nark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S. PACAP suppress dry eye signs by stimulating tear secretion. Nat Commun 7: 12034, 2016
  7. Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T. Involvement of GABAA receptors in 5-HT1A and sigma1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. Psychopharmacology (Berl) 233: 3125-3134, 2016
  8. Kawanai T, Ago Y, Watanabe R, Inoue A, Taruta A, Onaka Y, Hasebe S, Hashimoto H, Matsuda T, Takuma K. Prenatal exposure to histone deacetylase inhibitors affects gene expression of autism-related molecules and delays neuronal maturation. Neurochem Res 41: 2574-2584, 2016
  9. Kormos V, Gaspar L, Kovacs LA, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglodi D, Helyes Z, Gaszner B. Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brain stem centers. Neurosci 330: 335-358, 2016
  10. Sandor B, Fintor K, Reglodi D, Fulop DB, Helyes Z, Szanto I, Nagy P, Hashimoto H, Tamas A. Structural and morphometic comparison of lower incisors in PACAP-deficient and wild-type mice. J Mol Neurosci 59: 300-308, 2016
  11. Egri P, Fekete C, Denes A, Reglodi D, Hashimoto H, Fulop BD, Gereben B. Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates the hypothalamo-pituitary-thyroid (HPT) axis via Type 2 deiodinase in male mice. Endocrinol 157: 2356-2366, 2016
  12. Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S. Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke. J Mol Neurosci 59: 270-279, 2016
  13. Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S. Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. Sci Rep 6: 22373, 2016
  14. Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K. Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproric acid-induced autism. Autism Res 9: 926-939, 2016
  15. Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, Yamashita T. Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mice. Transl Psychiatry 6:e766, 2016
  16. Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda R, Hashimoto R, Hashimoto H. De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ. J Mol Psychiatry 4: 1, 2016
  17. Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H. Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. J Human Genet 61: 199-206, 2016
  18. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun 7: 10594, 2016
  19. Higashino K, Ago Y, Umeki T, Hasebe S, Onaka Y, Hashimoto H, Takuma K, Matsuda T. Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice. Psychopharmacology (Berl) 233: 521-528, 2016

2015年

  1. Watanabe K, Palonpon AF, Smith NI, Chiu LD, Kasai A, Hashimoto H, Kawata S, Fujita K. Structured line illumination Raman microscopy. Nat Commun 6: 10095, 2015
  2. Ikeda K, Tomimoto S, Tsuchiya S, Hamagami K, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H. Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice. Biochem Biophys Rep 2: 179-183, 2015
  3. Kawanai T, Taruta A, Inoue A, Watanabe R, Ago Y, Hashimoto H, Hasebe S, Ooi Y, Takuma K, Matsuda T. Decreased expression of hippocampal Na+/Ca2+ exchanger isoform-1 by pentylenetetrazole kindling in mice. Epilepsy Res 115: 109-112, 2015
  4. Ago Y, Hasebe S, Nishiyama S, Oka S, Onaka Y, Hashimoto H, Takuma K, Matsuda T. The female encounter test, a novel method for evaluating reward-seeking behavior or motivation in mice. Int J Neuropsychopharmacol 18(11). pii: pyv062., 2015
  5. Helyes Z, Kun J, Dobrosi N, S$00E1ndor K, N$00E9meth J, Perkecz A, Pint$00E9r E, Szabadfi K, Gaszner B, T$00E9kus V, Szolcs$00E1nyi J, Steinhoff M, Hashimoto H, Regl$0151di D, B$00EDr$00F3 T. Pituitary Adenylate-Cyclase Activating Polypeptide is up-Regulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema. J Invest Dermatol 135: 2209-2218, 2015
  6. Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T. Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behav Pharmacol 26: 681-690, 2015
  7. Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami KI, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimoto H. p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice.Biochem Biophys Res Commun 461: 612-617, 2015
  8. Shibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, K$00F6ves K, Regl$0151di D, Tamas A, Matsuda T, Baba A, Hashimoto H. Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide. Neuroscience 297: 95-104, 2015
  9. Hara Y, Takuma K, Takano E, Katashiba K, Taruta A, Higashino K, Hashimoto H, Ago Y, Matsuda T. Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model. Behav Brain Res 289: 39-47, 2015
  10. Tsumuraya T, Ohtaki H, Song D, Sato A, Watanabe J, Hiraizumi Y, Nakamachi T, Xu Z, Dohi K, Hashimoto H, Atsumi T, Shioda S. Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP). J Neuroinflammation 12: 35, 2015
  11. Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB. A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. PLoS One 10: e0121707, 2015
  12. Ogata K, Shintani N, Hayata-Takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudry D, Vaudry H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PLoS One 10: e0120526, 2015
  13. Hasebe S, Hiramatsu N, Ago Y, Mori K, Watabe Y, Hashimoto H, Takuma K, Matsuda T. Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice. J Pharmacol Sci 127: 232-235, 2015
  14. Ago Y, Condro MC, Tan YV, Ghiani CA, Colwell CS, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA. Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist. Psychopharmacology (Berl) 232: 2181-2189, 2015
  15. Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata KY, Nakamura M, Hashimoto R, Matsuda T, Waschek JA, Kasai A, Nagayasu K, Baba A, Hashimoto H. CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. Behav Brain Res 284: 131-137, 2015
  16. Ota Y, Ago Y, Tanaka T, Hasebe S, Toratani Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T Anxiolytic-like effects of restraint during the dark cycle in adolescent mice. Behav Brain Res 284: 103-111, 2015
  17. Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H. Simultaneous neuron- and astrocyte-specific fluorescent marking. Biochem Biophys Res Commun 459: 81-86, 2015
  18. Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, Matsuda T, Baba A, Hashimoto H Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro. J Neurochem 132: 418-428, 2015

2014年

  1. Banki E, Pakai E, Gaszner B, Zsiboras C, Czett A, Bhuddi PR, Hashimoto H, Toth G, Tamas A, Reglodi D, Garami A Characterization of the thermoregulatory response to pituitary adenylate cyclase-activating polypeptide in rodents. J Mol Neurosci 54: 543-554, 2014
  2. Botz B, Bolcskei K, Kereskai L, Kovacs M, Nemeth T, Szigeti K, Horvath I, Mathe D, Kovacs N, Hashimoto H, Reglodi D, Szolcsanyi J, Pinter E, Mocsai A, Helyes Z Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model. Arthritis Rheumatol 66: 2739-2750, 2014
  3. Haba R, Shintani N, Onaka Y, Kanoh T, Wang H, Takenaga R, Hayata A, Hirai H, Nagata KY, Nakamura M, Kasai A, Hashimoto R, Nagayasu K, Nakazawa T, Hashimoto H, Baba A Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci 34: 2514-2523, 2014
  4. Hazama K, Hayata-Takano A, Uetsuki K, Kasai A, Encho N, Shintani N, Nagayasu K, Hashimoto R, Reglodi D, Miyakawa T, Nakazawa T, Baba A, Hashimoto H Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice. PLoS One 9: e89153, 2014
  5. Maasz G, Pirger Z, Reglodi D, Petrovics D, Schmidt J, Kiss P, Rivnyak A, Hashimoto H, Avar P, Jambor E, Tamas A, Gaszner B, Mark L Comparative protein composition of the brains of PACAP-deficient mice using mass spectrometry-based proteomic analysis. J Mol Neurosci 54: 310-319, 2014
  6. Nemeth A, Szabadfi K, Fulop B, Reglodi D, Kiss P, Farkas J, Szalontai B, Gabriel R, Hashimoto H, Tamas A Examination of calcium-binding protein expression in the inner ear of wild-type, heterozygous and homozygous pituitary adenylate cyclase-activating polypeptide (PACAP)-knockout mice in kanamycin-induced ototoxicity. Neurotox Res 25: 57-67, 2014
  7. Sandor B, Fintor K, Felszeghy S, Juhasz T, Reglodi D, Mark L, Kiss P, Jungling A, Fulop BD, Nagy AD, Hashimoto H, Zakany R, Nagy A, Tamas A Structural and morphometric comparison of the molar teeth in pre-eruptive developmental stage of PACAP-deficient and wild-type mice. J Mol Neurosci 54: 331-341, 2014
  8. Shintani N, Onaka Y, Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, Yagasaki Y, Nabeshima T, Takeda M, Hashimoto H Behavioral characterization of mice overexpressing human dysbindin-1. Mol Brain 7: 74, 2014
  9. Takuma K, Hara Y, Kataoka S, Kawanai T, Maeda Y, Watanabe R, Takano E, Hayata-Takano A, Hashimoto H, Ago Y, Matsuda T Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. Pharmacol Biochem Behav 126: 43-49, 2014
  10. Takuma K, Maeda Y, Ago Y, Ishihama T, Takemoto K, Nakagawa A, Shintani N, Hashimoto H, Baba A, Matsuda T An enriched environment ameliorates memory impairments in PACAP-deficient mice. Behav Brain Res 272: 269-278, 2014

2013年

  1. Ago Y, Hiramatsu N, Ishihama T, Hazama K, Hayata-Takano A, Shibasaki Y, Shintani N, Hashimoto H, Kawasaki T, Onoe H, Chaki S, Nakazato A, Baba A, Takuma K, Matsuda T The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide. Behav Pharmacol 24: 74-77, 2013
  2. Ago Y, Yano K, Araki R, Hiramatsu N, Kita Y, Kawasaki T, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. Neuropharmacology 65: 29-38, 2013
  3. Arata S, Nakamachi T, Onimaru H, Hashimoto H, Shioda S Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse. Eur J Neurosci 37: 407-416, 2013
  4. Botz B, Imreh A, Sandor K, Elekes K, Szolcsanyi J, Reglodi D, Quinn JP, Stewart J, Zimmer A, Hashimoto H, Helyes Z Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions. Peptides 43: 105-112, 2013
  5. Inoue H, Shintani N, Sakurai Y, Higashi S, Hayata-Takano A, Baba A, Hashimoto H PACAP Inhibits beta-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density. Front Endocrinol (Lausanne) 4: 27, 2013
  6. Tanida M, Hayata A, Shintani N, Yamamoto N, Kurata Y, Shibamoto T, Morgan DA, Rahmouni K, Hashimoto H Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner. Neuroscience 238: 297-304, 2013
  7. Toth ZE, Heinzlmann A, Hashimoto H, Koves K Distribution of secretin receptors in the rat central nervous system: an in situ hybridization study. J Mol Neurosci 50: 172-178, 2013

2012年

  1. Ago Y, Araki R, Yano K, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice. J Pharmacol Sci 118: 295-298, 2012
  2. Brubel R, Kiss P, Vincze A, Varga A, Varnagy A, Bodis J, Mark L, Jambor E, Maasz G, Hashimoto H, Helyes Z, Toth G, Tamas A, Koppan M, Reglodi D Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility. J Mol Neurosci 48: 623-630, 2012
  3. Gaszner B, Kormos V, Kozicz T, Hashimoto H, Reglodi D, Helyes Z The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger-Westphal nucleus, ventral lateral septum, and dorsal raphe nucleus. Neuroscience 202: 283-299, 2012
  4. Haba R, Shintani N, Onaka Y, Wang H, Takenaga R, Hayata A, Baba A, Hashimoto H Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala. Behav Brain Res 228: 423-431, 2012
  5. Hattori S, Takao K, Tanda K, Toyama K, Shintani N, Baba A, Hashimoto H, Miyakawa T Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice. Front Behav Neurosci 6: 58, 2012
  6. Heinzlmann A, Kiss G, Toth ZE, Dochnal R, Pal A, Sipos I, Manczinger M, Szabo G, Hashimoto H, Koves K Intranasal application of secretin, similarly to intracerebroventricular administration, influences the motor behavior of mice probably through specific receptors. J Mol Neurosci 48: 558-564, 2012
  7. Kawasaki T, Marumo T, Shirakami K, Mori T, Doi H, Suzuki M, Watanabe Y, Chaki S, Nakazato A, Ago Y, Hashimoto H, Matsuda T, Baba A, Onoe H Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor. J Cereb Blood Flow Metab 32: 1737-1746, 2012
  8. Markovics A, Kormos V, Gaszner B, Lashgarara A, Szoke E, Sandor K, Szabadfi K, Tuka B, Tajti J, Szolcsanyi J, Pinter E, Hashimoto H, Kun J, Reglodi D, Helyes Z Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice. Neurobiol Dis 45: 633-644, 2012
  9. Reglodi D, Kiss P, Szabadfi K, Atlasz T, Gabriel R, Horvath G, Szakaly P, Sandor B, Lubics A, Laszlo E, Farkas J, Matkovits A, Brubel R, Hashimoto H, Ferencz A, Vincze A, Helyes Z, Welke L, Lakatos A, Tamas A PACAP is an endogenous protective factor-insights from PACAP-deficient mice. J Mol Neurosci 48: 482-492, 2012
  10. Sakurai Y, Inoue H, Shintani N, Arimori A, Hamagami K, Hayata-Takano A, Baba A, Hashimoto H Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in beta cells. J Mol Neurosci 48: 647-653, 2012
  11. Shimada T, Takai Y, Shinohara K, Yamasaki A, Tominaga-Yoshino K, Ogura A, Toi A, Asano K, Shintani N, Hayata-Takano A, Baba A, Hashimoto H A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells. J Neurochem 122: 81-93, 2012
  12. Szabadfi K, Atlasz T, Kiss P, Danyadi B, Tamas A, Helyes Z, Hashimoto H, Shintani N, Baba A, Toth G, Gabriel R, Reglodi D Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo. Neurotox Res 21: 41-48, 2012
  13. Tajiri M, Hayata-Takano A, Seiriki K, Ogata K, Hazama K, Shintani N, Baba A, Hashimoto H Serotonin 5-HT(7) receptor blockade reverses behavioral abnormalities in PACAP-deficient mice and receptor activation promotes neurite extension in primary embryonic hippocampal neurons: therapeutic implications for psychiatric disorders. J Mol Neurosci 48: 473-481, 2012
  14. Tamas A, Szabadfi K, Nemeth A, Fulop B, Kiss P, Atlasz T, Gabriel R, Hashimoto H, Baba A, Shintani N, Helyes Z, Reglodi D Comparative examination of inner ear in wild type and pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. Neurotox Res 21: 435-444, 2012
  15. Tsuchikawa D, Nakamachi T, Tsuchida M, Wada Y, Hori M, Farkas J, Yoshikawa A, Kagami N, Imai N, Shintani N, Hashimoto H, Atsumi T, Shioda S Neuroprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on spinal cord injury. J Mol Neurosci 48: 508-517, 2012

2011年

  1. Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission. Psychopharmacology (Berl) 217: 443-452, 2011
  2. Ago Y, Yoneyama M, Ishihama T, Kataoka S, Kawada K, Tanaka T, Ogita K, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis. Neuroscience 172: 554-561, 2011
  3. Elekes K, Sandor K, Moricz A, Kereskai L, Kemeny A, Szoke E, Perkecz A, Reglodi D, Hashimoto H, Pinter E, Szolcsanyi J, Helyes Z Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: in vivo study with gene-deleted mice. Peptides 32: 1439-1446, 2011
  4. Endo K, Nakamachi T, Seki T, Kagami N, Wada Y, Nakamura K, Kishimoto K, Hori M, Tsuchikawa D, Shinntani N, Hashimoto H, Baba A, Koide R, Shioda S Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse. J Mol Neurosci 43: 22-29, 2011
  5. Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A PACAP is implicated in the stress axes. Curr Pharm Des 17: 985-989, 2011
  6. Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice. Neuropharmacology 60: 397-404, 2011
  7. Sakurai Y, Shintani N, Arimori A, Hamagami K, Higuchi N, Inoue H, Ikeda K, Hayata A, Hashimoto H, Baba A Cerulein-induced acute pancreatitis in PACAP knockout mice. J Mol Neurosci 43: 8-15, 2011
  8. Sakurai Y, Shintani N, Hayata A, Hashimoto H, Baba A Trophic effects of PACAP on pancreatic islets: a mini-review. J Mol Neurosci 43: 3-7, 2011
  9. Szakaly P, Laszlo E, Kovacs K, Racz B, Horvath G, Ferencz A, Lubics A, Kiss P, Tamas A, Brubel R, Opper B, Baba A, Hashimoto H, Farkas J, Matkovits A, Magyarlaki T, Helyes Z, Reglodi D Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury. Neuropeptides 45: 113-121, 2011
  10. Tanida M, Shintani N, Hashimoto H The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide. Neurosci Res 70: 55-61, 2011
  11. Tsukiyama N, Saida Y, Kakuda M, Shintani N, Hayata A, Morita Y, Tanida M, Tajiri M, Hazama K, Ogata K, Hashimoto H, Baba A PACAP centrally mediates emotional stress-induced corticosterone responses in mice. Stress 14: 368-375, 2011
  12. Vincze A, Reglodi D, Helyes Z, Hashimoto H, Shintani N, Abraham H Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: lessons from PACAP-deficient mice. Int J Dev Neurosci 29: 923-935, 2011

2010年

  1. Ferencz A, Nedvig K, Fekecs T, Racz B, Weber G, Hashimoto H, Baba A, Helyes Z, Reglodi D Comparison of intestinal cold preservation injury on pituitary adenylate cyclase-activating polypeptide in knockout and wild-type mice. Transplant Proc 42: 2290-2292, 2010
  2. Ferencz A, Weber G, Helyes Z, Hashimoto H, Baba A, Reglodi D Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury. J Mol Neurosci 42: 428-434, 2010
  3. Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neurosci Lett 468: 300-302, 2010
  4. Hatanaka M, Shibata N, Shintani N, Haba R, Hayata A, Hashimoto H, Baba A 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. J Pharmacol Sci 113: 89-93, 2010
  5. Horvath G, Mark L, Brubel R, Szakaly P, Racz B, Kiss P, Tamas A, Helyes Z, Lubics A, Hashimoto H, Baba A, Shintani N, Furjes G, Nemeth J, Reglodi D Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro. Neurosci Lett 469: 70-74, 2010
  6. Horvath G, Racz B, Szakaly P, Kiss P, Laszlo E, Hau L, Tamas A, Helyes Z, Lubics A, Hashimoto H, Baba A, Reglodi D Mice deficient in neuropeptide PACAP demonstrate increased sensitivity to in vitro kidney hypoxia. Transplant Proc 42: 2293-2295, 2010
  7. Ishihama T, Ago Y, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice. Behav Brain Res 209: 274-280, 2010
  8. Kawaguchi C, Isojima Y, Shintani N, Hatanaka M, Guo X, Okumura N, Nagai K, Hashimoto H, Baba A PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset. PLoS One 5: e9286, 2010
  9. Kemeny A, Reglodi D, Cseharovszky R, Hashimoto H, Baba A, Szolcsanyi J, Pinter E, Helyes Z Pituitary adenylate cyclase-activating polypeptide deficiency enhances oxazolone-induced allergic contact dermatitis in mice. J Mol Neurosci 42: 443-449, 2010
  10. Mori H, Nakamachi T, Ohtaki H, Yofu S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice. Circ J 74: 1183-1190, 2010
  11. Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, Sato A, Hashimoto H, Shintani N, Baba A, Shioda S Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain. Acta Neurochir Suppl 106: 43-46, 2010
  12. Nakata M, Shintani N, Hashimoto H, Baba A, Yada T Intra-islet PACAP protects pancreatic beta-cells against glucotoxicity and lipotoxicity. J Mol Neurosci 42: 404-410, 2010
  13. Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, Shioda S Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor. J Mol Neurosci 42: 397-403, 2010
  14. Purwana IN, Kanasaki H, Oride A, Mijiddorj T, Shintani N, Hashimoto H, Baba A, Miyazaki K GnRH-induced PACAP and PAC1 receptor expression in pituitary gonadotrophs: a possible role in the regulation of gonadotropin subunit gene expression. Peptides 31: 1748-1755, 2010
  15. Sandor K, Kormos V, Botz B, Imreh A, Bolcskei K, Gaszner B, Markovics A, Szolcsanyi J, Shintani N, Hashimoto H, Baba A, Reglodi D, Helyes Z Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice. Neuropeptides 44: 363-371, 2010
  16. Tanaka K, Kunishige-Yamamoto A, Hashimoto H, Shintani N, Hayata A, Baba A Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice. Biochem Biophys Res Commun 391: 773-777, 2010
  17. Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai K Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide. Regul Pept 161: 73-80, 2010
  18. Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, Shintani N, Baba A, Kumamoto N, Yamada K, Yoshikawa T, Katayama T, Tohyama M Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations. PLoS One 5: e8596, 2010
連絡先
〒565-0871
大阪府吹田市山田丘1-6
大阪大学大学院薬学研究科
神経薬理学分野
教授　橋本 均
TEL：06-6879-8180
FAX：06-6879-8184